Improving retinal mitochondrial function as a treatment for age-related macular degeneration

https://www.sciencedirect.com/science/article/pii/S221323172030094X Published:           July 2020   Abstract Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly.  Currently, there are no treatments for dry AMD, which is characterized by the death of retinal pigment epithelium (RPE) and photoreceptors. Reports from human donors with AMD suggest that RPE mitochondrial defects are a key event …

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NMN administration after sever hypoglycemia improves neuronal survival and cognitive function

https://pubmed.ncbi.nlm.nih.gov/32380185/ Published:                July 2020   Highlights Nicotinamide mononucleotide improves learning and memory after severe hypoglycemia. Nicotinamide mononucleotide improves neuronal survival after severe hypoglycemia. Nicotinamide mononucleotide eliminates ROS accumulation after severe hypoglycemia. Nicotinamide mononucleotide suppresses PARP-1 activity after severe hypoglycemia. Nicotinamide mononucleotide prevents severe hypoglycemia-induced LTP inhibition.   Abstract Hypoglycemia-induced brain injury is a potential complication …

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Therapeutic Potential of NAD-Boosting Molecules

Abstract Nicotinamide adenine dinucleotide (NAD), the cell’s hydrogen carrier for redox enzymes, is well known for its role in redox reactions.  More recently, it has emerged as a signalling molecule.  By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and …

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Mechanisms of transformation of NMN to cerebral infarction hemorrhage

https://www.sciencedirect.com/science/article/pii/S1319562X19303237 Published:           December 2019   Abstract Objective: The study aims at discussing the effect of nicotinamide mononucleotides on protecting hemorrhagic transformation of cerebral infarction in the middle cerebral artery occlusion (MCAO) model. Method: Male mice aged 4–5 weeks and weighing about 22–35 g in Shanghai Ninth People’s Hospital are divided into three groups: sham group, …

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Administration of NMN Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226525/ Published:  March 2020 Abstract Maternal obesity impacts offspring metabolism.  We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and long-term post weaning over-nutrition. Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 …

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Nicotinamide mononucleotide (NMN) improves the depression-like behaviors

Background:   Nicotinamide mononucleotide (NMN) has been shown to stimulate oxidative phosphorylation in mitochondria and to improve various pathologies in patients and mouse disease models.  However, whether NMN mediates mitochondrial energy production and its mechanism of action in depressed animals remain unclear. Methods:   Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day …

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