What is Nicotinamide Mononucleotide (NMN)?
Nicotinamide Mononucleotide is an intermediate molecule made in the conversion of both nicotinamide and nicotinamide riboside to NAD+. It is a type of molecule called a nucleotide, which is very similar to the building blocks of DNA.
Some fantastic results with NMN
- Treatment of old mice with NMN reversed all of these biochemical aspects of aging.
- After just one week, researchers examined the tissue of the 2 year old mice and found that it closely resembled the tissue of
six month old mice. Researchers concluded that “this would be like a 60-year-old converting to a 20-year-old.”
- The cells of old mice were indistinguishable from young mice after just one week of
- Increases NAD+ and Sirtuin levels, which are a key molecules needed for DNA repair.
- Supplementation with NMN was able to repair the DNA in ceils damaged by radiation (NASA conducting more research).
- Raising NAD+ levels in old mice restores mitochondrial function to that of a young MOUSE.
- NMN treated mice showed better immune function. Better functioning of the immune system means less infections and less cancer.
Improve Brain Function
- NMN treatment reduces brain cell death and oxidative stress. These results further support the neuroprotection by
- A recent study indicates that NMN could restore cognition in Alzheimer Disease in rats
- NMN Treatment rescues (improves) cognitive impairments.
- Replenishment of NAD+ has been shown to protect against brain disorders such as amyotrophic lateral sclerosis and ischemic stroke.
Heart & Vascular System
- Scientists have reversed vascular atrophy, restored vessel growth in mice with NMN.
- Remarkably, NMN administered
to mice restores cardiac function to near-normal levels.
- NMN treatment significantly reduced brain edema, brain cell death, oxidative stress, neuroinflammation and myocardial inflammation.
- Neovascularization (growth of new blood vessels) is as important as mitochondria for rejuvenating muscle.
- Researchers found that NMN also dropped cholesterol and triglyceride levels. However, this drop was primarily seen in those mice on high-dose NMN
Muscle, Endurance & Weight
- Mice given NMN were much more energetic and had better energy production from their mitochondria.
- Research found mice fed low- dose NMN lost 4% of their body weight. Those fed high-dose NMN lost 9% of their body weight. Even more remarkable was that even though the mice on NMN ate much more, they still lost weight!
- NMN suppresses age-associated body weight gain, enhances energy metabolism and mimics and augments exercise.
- Mice treated with NMN also had stronger muscles and bones. Interestingly, the 513 genes that cause loss of muscle and bone density with aging were all Suppressed with NMN ina
Diabetes & Vision
- NMN improves insulin sensitivity
and eye function with no toxicity.
- Mice on NMN showed much better insulin sensitivity. Better insulin sensitivity means less diabetes.
- Exogenous (from external) NMN prevents photoreceptor degeneration and restores vision.
- Older mice were even less likely to suffer from dry eyes.
- Surprisingly, just one dose of NUN normalized impaired glucose tolerance.
- Administering NMN, a key NAD+ intermediate, can be an effective intervention to treat the pathophysiology of diet- and age-induced Type 2 Diabetes.
FAR more increase of NAD+ from NMN
Homeostasis refers to the ability of the body or a cell to seek and maintain a condition of equilibrium or stability within its internal environment when dealing with external changes.
Although NR and NMN are very similar in their effect on NAD+ levels from a single dose, homeostasis appears to impact NR much more quickly than NMN, impacting its ability to maintain increased levels of NAD+.
NMN is transported directly into cells.
NR is converted to NMN before being converted to NAD+
Homeostasis limits long-term increase of NAD+ with NR.
NMN is effective at higher dosages for longer than NR.
NMN Bypasses the NAMPT limiting step
Why is NAD+ Important?
NAD+ is required not only for life but for a long life. It is a molecule found in every cell in the body. NAD+ is used to power our metabolism, by enabling the mitochondria to convert the food we eat into the energy our body needs to sustain all its functions. It is also required to “turn off” genes implicated in accelerating the aging processes. NAD+ levels decline as we age. NAD+ has many important roles for health, including stimulating anti-aging activities of Sirtuins and the DNA damage repair enzymes.
Research revealed that mitochondrial dysfunction is “reversible” with supplementation to boost NAD+. NMN is the immediate precursor to NAD+. The health benefits under investigation strongly suggest that there are significant benefits to be derived from NMN supplementation which, even if they do not extend life expectancy, should result in improved quality of life with fewer illnesses and declines in our body’s organs.
You may still only live to age 80, however your “healthspan” will be better with stronger bones, more energy, better eyesight, improved vascular system, improved insulin sensitivity and a clearer functioning brain. Giving you a much more enjoyable life, free from debilitating diseases usually associated with aging. If life is extended, then you can remain active and healthy for as long as possible.
If your lifespan is not extended, instead of spending the last 10 to 20 years being sick, you can continue to function normally until you reach the very end, still in good health, or at worst, only in poor health for a short period, rather than decades.
Is NMN Safe?
NMN is found in foods such as broccoli, cabbage, cucumber, edamame and avocado. Studies have shown that NMN is Non-toxic.
NMN is available in vegetables, mushrooms, meat, and shrimp but trying to obtain sufficient through diet alone would be problematic. Studies dosages have been about 50mg – 250mg.
The FDA suggests that a 68kg human would require about 560mg per day. The difficulty is that you would have to eat about 45kgs of edamame, 81kgs of broccoli, or similarly impossible amounts of cucumber, cabbage, avocado, tomato, mushrooms, raw beef, or shrimp.
Mice can’t have all the fun, of course, so human studies (conducted in Tokyo’s Keio University School of Medicine and the Washington University School of Medicine) are currently in progress (concluding June 1st, 2020) to determine change in insulin sensitivity, and to determine change in beta-cell function over the course of two years with NMN supplementation.
Researchers also expect to gather results on control of blood sugar, dilation of blood vessels, changes in both blood lipid and body fat levels, and changes in the markers for cardiovascular disease.
The first human trials of NMN commence in Sept 2016 in Japan. Subsequent human studies have been undertaken. Dr David Sinclair complete his phase I study and is now commencing Phase II. If there were safety issue identified in Phase I then Phase II would not go ahead or would be delayed.
Improve your biological age and health-span, not just your lifespan
Living longer does not guarantee a better quality of life. Continue to enjoy a longer, good
healthy life, with increased physical and mental energy, and reduced aging problems.
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