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1 x 60x300mg PEA Capsules

$18.50

Discovered in 1957, Palmitoylethanolamide (PEA) is a natural and powerful active compound that has been extensively studied with over 1,200 scientific studies being undertaken.    PEA appears to be a powerful, natural painkiller anti-inflammatory and significant analgesic power.

With recognised efficacy, PEA supplementation offers significant therapeutic potential for relieving both acute and chronic pain, be it inflammatory, neuropathic or a combination of the two.  PEA’s benefits are now available as a nutritional supplement in capsule form.

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Description

What is palmitoylethanolamide (PEA)?

PEA (palmitoylethanolamide) is a compound naturally produced by your body and is used for chronic pain and inflammation management and small quantities can be found in foods such as meat, eggs, milk, soybeans and peanuts.

PEA is a promising addition to therapeutic management of neuropathic pain with good tolerability and low propensity for side effects.

Studies have shown PEA has pain relieving and anti-inflammatory properties useful in numerous chronic pain states and has been shown to be effective in:-

  • sciatic pain
  • low back pain
  • carpal tunnel syndrome
  • diabetic neuropathic pain
  • neuralgia
  • fibromyalgia
  • multiple sclerosis and
  • severe neuropathic pain.

In 2016, titled: Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy, found 21 clinical studies, of which 16 were clinical trials enrolling a range of 20 to 636 patients and five were case/pilot studies.  In the clinical trials, PEA was used for periods ranging from 14 days to 120 days, and the doses ranged from 300 mg to 1200 mg daily.  The authors concluded on the basis of their analyses that PEA was an effective treatment for pain with no registered serious adverse effects.

PEA’s powerful pain-killing activity

Pea Reduce Pain 2560

Inflammation- and pain-regulating effects

In humans as in other living beings, PEA plays a role in several biological functions.  In the human body, it is primarily known for its painkilling and anti-inflammatory activity.

Research has shown that this compound is able to bind to specific receptors, activated by peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are involved in the regulation of pain and inflammation genes.

In binding to these receptors, PEA thus modulates pain and inflammatory responses.

Effects on the perception of pain

As well as helping to regulate pain, PEA also appears to have other pain-relieving effects.  In particular, it seems to act on CB1 and CB2 cannabinoid receptors which are involved in the immune response and perception of pain.

PEA also appears to have an effect on TRPV1 receptors which play a role in nociception, the sensory process responsible for the most common types of pain – acute or nociceptive pain.

A natural compound with significant therapeutic potential

Therapeutic potential of PEA

As a result of its analgesic potency, PEA is often described as a natural, universal painkiller, able to combat both acute and chronic pain.  It offers relief from pain of inflammatory and neuropathic origin, as well as that caused by a combination of the two1,2,3..

Benefits of PEA supplementation

PEA is a fatty acid amide which can be synthesised from phospholipids. While it can be produced within the body, PEA can also be hydrolysed by certain enzymes but this hydrolysis greatly reduces its activity. That is why scientists are investigating the benefits of supplementing with PEA. Their research has demonstrated benefits against dental, lumbar and pelvic pain as well as that associated with compression of the sciatic nerve, arthritis, carpal tunnel syndrome, glaucoma, diabetic neuropathy and multiple sclerosis1,2,3,4.. According to recent studies, it could also be useful in treating inflammatory diseases such as uveitis and ulcerative colitis5..

Recognised efficacy of PEA supplementation

Large-scale study on PEA’s painkilling effect

To confirm the benefits of supplementing with PEA, a large-scale study was conducted among a group of people suffering from sciatic pain⁴.  Aged between 19 and 72, the 636 male and female volunteers were divided into three groups:

  1. Group 1 was the control group and received a placebo;
  2. Group 2 were given 300mg/day of PEA ;
  3. Group 3 received 600mg/day of PEA.

The three-week study highlighted significant differences between the control group and the two supplemented groups.  Using a questionnaire, as well as clinical and laboratory tests, the researchers observed differences, in particular, in perception of pain and quality of life, with both PEA-supplemented groups displaying a decrease in pain perception.

Improvements in quality of life were also reported by participants.  These improvements were dose-dependent – in those given the 600mg dose of PEA, a reduction in pain of almost 50% was observed. This exceptional finding thus confirms the efficacy of PEA as a painkiller.  Furthermore, no drug interactions or troublesome side effects have been described so far.

Promising results in relation to chronic inflammation of the colon

In addition to its pain-relief effects, PEA is also attracting scientific interest for its anti-inflammatory activity.  One study, published in the prestigious journal Gut, investigated PEA’s effects against certain forms of chronic colon inflammation such as ulcerative colitis and haemorrhagic rectocolitis5.

Efficacy was evaluated in mouse models with induced colitis, in colon tissue taken from patients with ulcerative colitis and in cultures of enteric glial cells which are involved in the inflammatory process.

Using a number of different analyses, researchers reported significant and consistently positive results: an improvement in symptoms of ulcerative colitis and a decrease in pro-inflammatory markers.

To expand their understanding of PEA’s anti-inflammatory action, the study’s authors also compared their results with those obtained using PEA combined with antagonists of PPAR-alpha receptors.  In this case, no improvement was observed, confirming that it was PEA’s mechanism of action which was responsible for the improvements.

In binding to PPAR-alpha receptors, the compound has a role in regulating inflammation, thus helping to combat pain and inflammatory diseases.

Safety and Effectiveness of PEA

Studies indicate that PEA does not develop pharmacological tolerance or gradually lose effectiveness over time as occurs with opioids.  It has been shown to be safe for patients with no reported serious side effects and it is considered to lack acute or chronic toxicity.

It does not interfere with other medication therapies nor does it trigger drug-drug interactions.  There are no known contraindications for PEA, and patients with reduced kidney and liver function can be treated with PEA, as its metabolism is localised, cellular, and independent of kidney and liver functions.

Pea Natural 2560

PEA Dosage

The normal standard dose of PEA is 1 – 2 capsules twice a day.  The strength will sometimes vary according to the required strength advised by your local GP.  Normally 1-2 x 300mg capsules are given twice a day where treatment is seen to continue for 3-6 months.

Cautions

This content is not intended to be a substitute for professional medical advice, diagnosis or treatment.

Always see the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.  Never disregard professional medical advice or delay in seeking it because of something you have read.

This product may not be right for you.  Always read the label, warnings and instructions for use.  Vitamin and Mineral supplements should not replace a balanced diet.

If symptoms persist talk to your healthcare professional.

We make no therapeutic claims regarding our materials.  Therapeutic is defined by the Australian Therapeutic Goods Administration (TGA) as:

  • Influencing, inhibiting or modifying a physiological process in people or animals ; and /or
  • Testing the susceptibility of persons or animals to a disease ailment; and/or
  • Influencing, controlling or preventing conception in persons; and/or
  • Preventing, diagnosing, curing or alleviating a disease, ailment, defect or injury in a person or animal.

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