Reference: https://pubmed.ncbi.nlm.nih.gov/39873717/
A recent study explored the potential of apigenin, a natural compound found in various fruits and vegetables, to improve memory in mice subjected to stress. Researchers aimed to understand how apigenin might counteract stress-induced memory problems by examining its effects on brain chemistry and hormone levels.
In this study, male mice were exposed to chronic unpredictable mild stress (CUMS) for two weeks, a method used to simulate stress-related memory issues. Some of these stressed mice received daily doses of apigenin before their stress exposure. The researchers then assessed the mice’s memory using tests that measure their ability to recognize new objects and navigate mazes.
The findings revealed that stressed mice not given apigenin showed significant memory impairments. They also had higher levels of corticosterone, a stress hormone, and increased markers of oxidative stress, indicating cell damage. Additionally, these mice exhibited lower levels of natural antioxidants and reduced activity in brain pathways associated with learning and memory.
Conversely, stressed mice treated with apigenin demonstrated notable improvements in memory tests. Their corticosterone levels and oxidative stress markers were reduced, while antioxidant levels were restored. Moreover, apigenin treatment enhanced the activity of brain-derived neurotrophic factor (BDNF) and other proteins crucial for cognitive functions.
These results suggest that apigenin helps restore balance in the body’s stress response and oxidative systems, thereby improving memory. By boosting the BDNF/ERK/CREB signaling pathway, apigenin appears to support brain health and counteract the negative effects of stress on cognition.
While these findings are promising, it’s important to note that the study was conducted on mice. Further research is needed to determine if apigenin would have similar benefits in humans. Nonetheless, this study highlights the potential of natural compounds like apigenin in addressing stress-related cognitive issues.
Incorporating apigenin-rich foods, such as parsley, chamomile, and celery, into one’s diet might offer some cognitive benefits. However, before considering apigenin supplements or significant dietary changes, it’s advisable to consult with a healthcare professional.
In summary, the study indicates that apigenin may help improve memory in stressed mice by restoring hormonal and oxidative balance and enhancing brain signaling pathways related to learning. These insights pave the way for future research into natural approaches for managing stress-induced cognitive decline.
