NMN Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

https://pubmed.ncbi.nlm.nih.gov/32755581/   Abstract Advanced maternal age is highly associated with a decline in oocyte quality, but effective approaches to improve it have still not been fully determined.  Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously improves the quality of oocytes from naturally aged mice by recovering nicotinamide adenine dinucleotide (NAD+) levels. …

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Mitochondrial DNA mutation exacerbates female reproductive aging, and rescued by NMN

https://pubmed.ncbi.nlm.nih.gov/32744417/ First published: 03 August 2020                                                                     https://doi.org/10.1111/acel.13206   Abstract Mammals’ aging is correlated with the accumulation of mitochondrial DNA (mtDNA) mutations. Here, scientists analyzed oocyte (a cell in an ovary which may undergo meiotic division to form an ovum) quality of young (≤30 years old) and elder (≥38 years old) female patients and show the …

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Melatonin and NMN reduce Myocardial Ischemia Injury and Aging-induced Cognitive Impairment

In two recent studies we examine the effect of combining NMN and Melatonin on Ischemia Injury and Cognitive Impariment. Study 1 Published December 2019 Ischemic heart diseases are the major reasons for disability and mortality in elderly individuals.  In this study, we tried to examine the combined effects of nicotinamide mononucleotide (NMN) preconditioning and melatonin …

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NMN (Nicotinamide mononucleotide) supplementation promotes neurovascular rejuvenation in aged mice

Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion. There is increasing evidence showing that a decrease in NAD + availability with age plays a critical role in age-related neurovascular and cerebromicrovascular dysfunction.  Our recent studies demonstrate that restoring cellular NAD+ levels in aged mice rescues neurovascular function, increases cerebral blood …

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